Interrogating the Mechanistic Features of Ni(I)-Mediated Aryl Iodide Oxidative Addition Using Electroanalytical and Statistical Modeling Techniques

Tianhua Tang, Avijit Hazra, Daniel S. Min, Wendy L. Williams, Eli Jones, Abigail G. Doyle, and Matthew S. Sigman
Published: April 4, 2023
DOI: https://doi.org/10.1021/jacs.3c01726
JACS

The oxidative addition of Ni(I) to aryl iodide is a crucial step in many catalytic processes, but the in-depth mechanistic understanding of this fundamental process is still lacking. We have applied electroanalytical and statistical modeling studies to understand this important mechanistic event. Our analysis led to a classification of the oxidative addition mechanism, either through a three-centered concerted or a halogen atom abstraction mechanism based on the ligand type.